Ira A. Fulton Schools of Engineering

DDEL-10. A NANOPARTICLE PLATFORM FOR INTRATHECAL DELIVERY OF THE HISTONE DEACETYLASE INHIBITOR (HDACi) PANOBINOSTAT IN METASTATIC OR RECURRENT MEDULLOBLASTOMA S Chaudhuri, AS Mohammad, W Zhang, C Baker, CW Broughton, … Neuro-Oncology 22 (Supplement_3), iii285-iii285

Hyaluronic Acid Biomaterials for Central Nervous System Regenerative Medicine G Jensen, JL Holloway, SE Stabenfeldt Cells 9 (9), 2113

Extracellular matrix proteins are time‐dependent and regional‐specific markers in experimental diffuse brain injury DR Griffiths, TM Jenkins, CP Addington, SE Stabenfeldt, J Lifshitz Brain and behavior 10 (9), e01767

Stromal Cell-Derived Factor-1a Autocrine/Paracrine Signaling Contributes to Spatiotemporal Gradients in the Brain KN Hickey, SM Grassi, MR Caplan, SE Stabenfeldt Cellular and Molecular Bioengineering, 1-13

Extracellular matrix proteins are time‐dependent and regional‐specific markers in experimental diffuse brain injury DR Griffiths, TM Jenkins, CP Addington, SE Stabenfeldt, J Lifshitz Brain and Behavior, e01767

Sex-dependent macromolecule and nanoparticle delivery in experimental brain injury Vimala N Bharadwaj, Connor Copeland, Ethan Mathew, Jason Newbern, Trent R Anderson, Jonathan Lifshitz, Vikram D Kodibagkar, Sarah E Stabenfeldt Tissue Engineering Part A

Leveraging the Dynamic Blood-Brain Barrier for Central Nervous System Nanoparticle-based Drug Delivery Applications C Copeland, SE Stabenfeldt Current Opinion in Biomedical Engineering

β-Cyclodextrin-Poly (β-Amino Ester) Nanoparticles Are a Generalizable Strategy for High Loading and Sustained Release of HDAC Inhibitors Sauradip Chaudhuri, Martha Fowler, Afroz S Mohammad, Wenqui Zhang, Cassandra Baker, Colton Broughton, Brandon Knight, William Elmquist, Sarah Stabenfeldt, Rachael W Sirianni ChemRxiv

Uncovering temporally sensitive targeting motifs for traumatic brain injury via phage display Briana I Martinez, Gergey Alzaem Mousa, Kiera Fleck, Tara MacCulloch, Chris W Diehnelt, Nicholas Stephanopoulos, Sarah E Stabenfeldt bioRxiv

Current trends in biomarker discovery and analysis tools for traumatic brain injury BI Martinez, SE Stabenfeldt Journal of biological engineering 13 (1), 1-12

Molecular analysis of muscle progenitor cells on extracellular matrix coatings and hydrogels J Palade, A Pal, A Rawls, S Stabenfeldt, J Wilson-Rawls Acta Biomaterialia 97, 296-309

Functionalized microgels with fibrin binding elements TH Barker, AC Brown, LA Lyon, SE Stabenfeldt, N Welsch, J Nicosia US Patent App. 16/266,312

HDACI-LOADED NANOPARTICLES TO TREAT TRAUMATIC BRAIN INJURY Sarah Stabenfeldt, Gergey Mousa, Connor Copeland, Briana Martinez, Kamawela Leka, George Bjorklund, Kyle Householder, Jason Newbern, Rachael Sirianni JOURNAL OF NEUROTRAUMA

ACUTE TRAUMATIC BRAIN INJURY CANDIDATE BIOMARKERS DISCOVERED BY PHAGE DISPLAY B Martinez, N Stephanopoulos, C Diehnelt, S Stabenfeldt JOURNAL OF NEUROTRAUMA 36 (13), A109-A109

Biomimetic Strategies To Treat Traumatic Brain Injury by Leveraging Fibrinogen AC Brown, E Lavik, SE Stabenfeldt Bioconjugate chemistry 30 (7), 1951-1956

Nanoparticle delivery precision based on sex-dependent opening of the blood-brain barrier after brain injury Vimala N Bharadwaj, Connor Copeland, Trent R Anderson, Jonathan Lifshitz, Vikram Kodibagkar, Sarah Stabenfeldt 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence

Multi-biomarker detection following traumatic brain injury BA Cardinell, CP Addington, SE Stabenfeldt, JT La Belle Critical Reviews™ in Biomedical Engineering 47 (3)

Blood–brainbarrier disruption dictates nanoparticle accumulation following experimental brain injury VN Bharadwaj, RK Rowe, J Harrison, C Wu, TR Anderson, J Lifshitz, … Nanomedicine: Nanotechnology, Biology and Medicine 14 (7), 2155-2166

Martinez, BI, Stabenfeldt, SE*. Current trends in biomarker discovery and analysis tools for traumatic brain injury. Journal of Biological Engineering. 2019; 13: 16. DOI: 10.1186/s13036- 019-0145-8

Featured in the “2019 Emerging Investigators” Themed Issue

Bharadwaj, VN, Rowe, RK, Harrison, J, Wu, C, Anderson, TR, Lifshitz, J, Adelson, PD, Kodibagkar, VD, Stabenfeldt, SE*. Blood-brain barrier disruption dictates nanoparticle accumulation following experimental brain injury. Nanomedicine. 2018; 14(7): 2155-2166. DOI: 10.1016/j.nano.2018.06.004

Hickey, K, Stabenfeldt, SE*. Using Biomaterials to Modulate Chemotactic Signaling for Central Nervous System Repair. Biomedical Materials. 2018; 13(4): 044106. DOI: 10.1088/1748-605X/aaad82.

Householder, KT, DiPerna, DM, Chung, EP, Luning, R, Nguyen, D, Stabenfeldt, SE, Mehta, S, Sirianni, RW*. pH Driven Precipitation of Quisinostat onto PLA-PEG Nanoparticles Enables Treatment of Intracranial Glioblastoma. Colloids and Surfaces B: Biointerfaces. 2018; 166: 37-44. DOI: 10.1016/j.colsurfb.2018.02.048

Bharadwaj, VN, Nguyen, D, Kodibagkar, VD, Stabenfeldt, SE*. Nanoparticle-based therapeutics for brain injury. Advanced Healthcare Materials. 2018; 7(1): 1700668. DOI: 10.1002/adhm.201700668.

Marsh, W, Witten, A, Stabenfeldt, SE*. (2018) Exploiting Phage Display for Development of Novel Cellular Targeting Strategies. In: Sirianni R, Behkam B. (eds) Targeted Drug Delivery. Methods in Molecular Biology, vol 1831. Humana Press, New York, NY.

Dutta, D, Hickey, K, Salifu, M#, Fauer, C#, Willingham, C, Stabenfeldt, SE*. Spatiotemporal presentation of exogenous SDF-1 with PLGA nanoparticles modulates SDF-1/CXCR4 signaling axis in the rodent cortex. Biomaterials Science. 2017. 5: 1640–1651. DOI: 10.1039/C7BM00489C

Featured in the “2017 Emerging Investigators” Themed Issue

Dutta, D, Fauer, C, Hickey, K, Salifu, M#, and Stabenfeldt, SE*. Tunable delayed controlled release profile from layered polymeric microparticles. Journal of Materials Chemistry B. 2017; 5: 4487-4498. DOI: 10.1039/c7tb00138j

Featured in the “2017 Emerging Investigators” Themed Issue

Roussas, A, Martinez, BI, Addington, CP, Stabenfeldt, SE*. (2017) Regenerative strategies for the central nervous system. In Kusumi K and Wilson-Rawls J (Ed.), Innovations in Molecular Mechanisms and Tissue Engineering. Springer.

Bharadwaj, VN, Lifshitz, J, Adelson, PD, Kodibagkar, VD*, Stabenfeldt, SE*. Temporal assessment of nanoparticle accumulation after experimental brain injury: Effect of particle size. Scientific Reports. 2016;6: Article number: 29988. DOI:10.1038/srep29988

Addington, CP, Dharmaraj, S#, Heffernan, JM, Sirianni, RW, Stabenfeldt, SE*. Hyaluronic acid-laminin hydrogels improve neural stem cell retention and migration in vivo. Matrix Biology. 2016;16:30210-4. DOI: 10.1016/j.matbio.2016.09.007

Addington, CP, Cusick, A, Shankar, RV, Argwal, S, Stabenfeldt, SE*, Kodibagkar, VD*. Siloxane nanoprobes for labeling and dual modality functional imaging of neural stem cells. Annals of Biomedical Engineering.2016;44(3):816-827. DOI: 10.1007/s10439-015-15141

Featured on Journal Cover

Dutta, D, Salifu, M#, Sirianni, RW*, Stabenfeldt, SE*. Tailoring sub-micron PLGA particle release profiles via centrifugal fractioning. Journal of Biomedical Materials Research Part A.2016;104:688-696. DOI: 10.1002/jbm.a.35608. 2015

Addington, CP, Heffernan, JM, Tucker, EW#, Millar-Haskell, CS#, Sirianni, RW, Stabenfeldt, SE*. Hyaluronic acid-laminin hydrogel enhances neural stem cells response to chemotactic SDF- 1α gradients. Biomaterials. 2015. 72:11-19. DOI:10.1016/j.biomaterials.2015.08.041

Brown, AC, Dysart, MM, Clarke, KC, Stabenfeldt, SE, and Barker, TH*. Integrin α3β1 binding to fibronectin is dependent on the 9th type III repeat. The Journal of Biological Chemistry. 2015; 290(42):255534-47. DOI:10.1074/jbc.M115.656702

Dutta, D, Fauer, C#, Mulleneux, HL, Stabenfeldt, SE*. Tunable controlled release of bioactive SDF-1α via protein specific interactions within fibrin/nanoparticle composites. Journal of Materials Chemistry B. 2015; 3:7963-7973. DOI: 10.1039/C5TB00935A

Invited for thematic issue, “Bio-inspired and Natural Materials”

Addington, CP, Roussas, A, Dutta, D, Stabenfeldt, SE*. Endogenous repair signaling after brain injury and complementary bioengineering approaches to enhance neural regeneration. Biomarker Insights. 2015; 10(Suppl 1):43-60. DOI: 10.4137/BMI.S20062. PMID: 25983552 2014

Brown, AC^, Stabenfeldt, SE^, Ahn, B, Hannan, R, Dhada, K, Herman, E, Stefanelli, V, Guzzetta, N, Alexeev, A, Lam, WA, Lyon, LA, Barker, TH*. Ultrasoft microgels displaying emergent, platelet-like, behaviour. Nature Materials. 2014; 13:1108–1114. DOI:10.1038/NMAT4066. PMID: 25194701

Addington, CP, Pauken, C, Caplan, MR, Stabenfeldt, SE*. The role of SDF-1α-ECM crosstalk in determining neural stem cell fate. Biomaterials. 2014; 35(10): 3263-3272. DOI: 10.1016/j.biomaterials.2013.12.102. PMID: 24438907

Addington, CP, Pauken, C, Stabenfeldt, SE* (2014). Evaluating the spatial and temporal production of extracellular matrix proteins in neural tissue engineering constructs in vitro. In Leach J and Powell E (Ed.), Neuromethods: Extracellular Matrix. Springer.

Overstreet, D, Dutta, D, Stabenfeldt, SE*, Vernon, BL*. Injectable hydrogels. Journal of Polymer Science Part B: Polymer Physics. 2012; 50(13): 881-903.